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Showing posts with label Aging in Amrica. Show all posts
Showing posts with label Aging in Amrica. Show all posts

Friday, September 25, 2015

Study Finds Significant Differences in Frailty by Region and by Race Among Older Americans


Substantial differences by income also found
Newswise, September 25, 2015 — A large-scale survey of older Americans living at home or in assisted living settings found that 15 percent are frail, a diminished state that makes people more vulnerable to falls, chronic disease and disability, while another 45 percent are considered pre-frail, or at heightened risk of becoming physically diminished.

The Johns Hopkins Bloomberg School of Public Health study found frailty to be more prevalent in older people and more common among women and the poor. In addition, the study found wide regional differences in the U.S., with older people in central southern states more than three times as likely to be frail than those in the western states. 

The researchers also found significant racial differences, with blacks and Hispanics nearly twice as likely to be frail as whites.

The study is published in the September 2015 issue ofJournals of Gerontology: Medical Sciences.

Frailty, once thought of as a generalized fragile state that befalls some people as they get older, is increasingly considered a medical process in and of itself. 

Frailty is thought to be exhibited by a set of symptoms including weakness, exhaustion and limited mobility. It often progresses separately from any underlying conditions, and is also common among patients with chronic diseases such as heart disease and diabetes, especially in their advanced stages.

Understanding frailty, and finding ways to prevent its onset or slow its progression, could improve older people’s quality of life by extending their so-called robust years. It could also increase their chances of surviving surgery, for example; previous research has suggested that older, frail patients are less likely to survive major surgical procedures. 

Reducing frailty could lower health care costs, since frail persons are prone to falls and falls often lead to hospitalization. Hospital care is the largest component of Medicare spending.

Of their findings, the authors were most surprised by the significant racial and regional differences, says study leader Karen Bandeen-Roche, PhD, the Frank Hurley and Catharine Dorrier Professor and Chair of the Department of Biostatistics at the Johns Hopkins Bloomberg School of Public Health. The study is believed to be the first that examines regional differences in frailty in the U.S.

“We can’t really explain the regional differences,” says Bandeen-Roche, who also co-directs the Johns Hopkins Older Americans Independence Center and is a Core Faculty member at the Johns Hopkins Center on Aging and Health. 

“We know there are health differences across the country, differences in diet and to some extent exercise habits. Observing the relatively low prevalence in the mountain west, you can imagine an active lifestyle might be a factor.” 
As for the racial differences, Bandeen-Roche says it’s too early to speculate, noting that they could be due to any number of factors, and merit further study.

For the study, researchers drew on interviews with 7,439 participants in the 2011 National Health and Aging Trends Study, a longitudinal study of people age 65 and older drawn from Medicare records. 

Participants, who resided either at home or in an assisted living facility, completed a two-hour, in-person interview that assessed frailty using several criteria: exhaustion, weakness, low physical activity, shrinking and low walking speed. 

Participants were also asked about their medical history and ability to perform daily tasks such as meal preparation and other household activities. The researchers assessed probable dementia with a combination of questions and cognitive tests.

Among the survey’s other findings: Residents of assisted living facilities were more than twice as likely to be frail than those living in private homes. 

Prevalence increased with age, with 9 percent of those ages 65 to 69 found to be frail compared to 38 percent of those aged 90 or older. Among the frail, more than half had fallen in the previous year, and more than one-third had fallen several times, with 40 percent of those who had fallen being hospitalized.

As frailty becomes better understood, the researchers hope clinicians will develop recommendations that specifically address risks associated with frailty, for instance, having people engage in strengthening activities before major surgery. 

Such recommendations, if adapted by older people who had not yet slipped into advanced frailty, could help delay or even prevent its onset.

Aside from the 15 percent found to be frail, the researchers also found that 45 percent were what the authors deemed “pre-frail,” or older people who have begun to experience the same symptoms of frailty, but to a lesser extent. “It’s a question of degree,” Bandeen-Roche says. 

The so-called pre-frail are a prime target of study in order to help researchers understand the progression of frailty so doctors can develop recommendations – for instance, changes in diet or exercise – that could extend a person’s robust years.

“We would love for frailty assessment to become a standard component of assessment of older Americans,” Bandeen-Roche says. “Understanding frailty could potentially help us extend people’s quality of life into their later years.”
“Frailty in Older Adults: A Nationally Representative Profile in the United States” was written by Karen Bandeen-Roche, Christopher L. Seplaki, Jin Huang, Brian Buta, Rita R. Kalyani, Ravi Varadhan, Qian-Li Xue, Jeremy D. Walston and Judith D. Kasper.


Monday, August 31, 2015

Putting a Dollar Value to Family Caregivng


September 1, 2015 — Family caregivers in the U.S. provided 37 billion hours of care—worth an estimated $470 billion—to their parents, spouses, partners, and other adult loved ones in 2013, according to AARP Public Policy Institute’s new report, Valuing the Invaluable: 2015 Update. The total estimated economic value of this uncompensated care provided by the nation’s family caregivers surpassed total Medicaid spending ($449 billion), and nearly equaled the annual sales ($469 billion) of the four largest U.S. tech companies combined (Apple, Hewlett Packard, IBM, and Microsoft) in 2013. 

Family caregiving for relatives or close friends with chronic, disabling, or serious health problems so they can remain in their home is nearly universal today. In 2013, about 40 million family caregivers helped another adult loved one carry out daily activities (such as bathing or dressing, preparing meals, administering medications, driving to doctor visits, and paying bills).      
“Family caregiving today is much more complex, stressful, and costly for caregivers than ever before,” said AARP CEO Jo Ann Jenkins. “This new report shows some of the progress that’s been made to help caregivers, but we need to do much more in public policy, in the workplace, and in the health care system.”  
Family Caregivers in the Future
As Americans live longer and have fewer children, fewer family members will be available for older adults to rely on for everyday help in the future. The ratio of potential family caregivers to the growing number of older people has already begun a steep decline. In 2010, there were 7.2 potential family caregivers for every person age 80 and older. By 2030, that ratio will fall sharply to 4 to 1, and is projected to drop further to 3 to 1 in 2050.  
Impact of Caregiving on Jobs, Money, and Health
Family caregivers report that the stress of caregiving affects their physical and emotional health, finances, and their jobs.
  • More than half (55%) of family caregivers report being overwhelmed by the amount of care their family member needs.
  • Nearly 4 in 10 (38%) family caregivers report a moderate (20%) to high degree (18%) of financial strain as a result of providing care.  
  • In 2014, the majority (60%) of family caregivers had full- or part-time jobs.  

Strategies and Policies Needed to Help Caregivers
“Over the past four years since the last report came out, we’ve seen a number of new policies at the federal and state level that are improving awareness about family caregivers’ needs,” saidSusan C. Reinhard, RN, PhD, Senior Vice President and Director, AARP Public Policy Institute, and lead author of the new report.. “We need multiple approaches to better help caregiving families, including such things as tax credits, improved workplace flexibility, respite care, home care services, and better training of family caregivers. Solutions to support family caregivers will need to come from both the private and public sectors.”
The estimates in this report by AARP’s Public Policy Institute are based on a meta-analysis of 11 U.S.-based surveys of family caregivers conducted between 2009 and 2014. Estimates are based on about 40 million caregivers providing an average of 18 hours of care per week to a parent, spouse/partner, or other adult loved one, at an average value of $12.51 per hour. ‘Caregiver’ is defined as an adult age 18 and older providing care to a parent, spouse, or other adult loved one with their daily activities such as bathing or dress, preparing meals, and/or managing their finances, currently or within the last month.
Caregiving Resources:
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About AARP AARP is a nonprofit, nonpartisan organization, with a membership of nearly 38 million, that helps people turn their goals and dreams into real possibilities, strengthens communities and fights for the issues that matter most to families such as healthcare, employment and income security, retirement planning, affordable utilities and protection from financial abuse. We advocate for individuals in the marketplace by selecting products and services of high quality and value to carry the AARP name as well as help our members obtain discounts on a wide range of products, travel, and services.  A trusted source for lifestyle tips, news and educational information, AARP produces AARP The Magazine, the world's largest circulation magazine; AARP Bulletin; www.aarp.org; AARP TV & Radio; AARP Books; and AARP en EspaƱol, a Spanish-language website addressing the interests and needs of Hispanics. AARP does not endorse candidates for public office or make contributions to political campaigns or candidates.  The AARP Foundation is an affiliated charity that provides security, protection, and empowerment to older persons in need with support from thousands of volunteers, donors, and sponsors. AARP has staffed offices in all 50 states, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands. Learn more atwww.aarp.org.​

Friday, August 28, 2015

Physics Meets Biology to Defeat Aging

Newswise, August 28, 2015 — The scientific team of a new biotech company Gero in collaboration with one of the leading academics in the field of aging, Prof. Robert J. Shmookler Reis (current world record holder in life extension for model animals - 10 fold for nematodes), has recently brought new insights into biology of aging and age-related diseases, primarily, around the stability and stress resistance of certain gene regulatory networks.

 “In our work, we analyzed the stability of a simple gene network model and found that gene networks describing most common species are inherently unstable.

“Over time, it undergoes exponential accumulation of gene regulation deviations leading to diseases and death. We conjectured, that the instability is the cause of aging.

“However, should the repair systems be sufficiently effective, the gene network can stabilize so that the damage to the gene regulation can remain constrained along with mortality of the organism.” - says Dr. Peter Fedichev, Gero CSO.
The stable case of genetic networks described by their model fits the negligible senescence phenomena.

It's well known that negligibly senescent animals, such as naked mole rat, do not show signs of functional decline or any increase of mortality with age. The tissues of these species are exceptionally stress-resistant.

On the contrary, mortality rate in humans, and in the most of the other known species increases exponentially with age. The reproductive, regenerative functions and stress-resistance decline during the process of aging. 
These are the manifestations of the underlying gene network instability.

According to the model, the stability of gene network depends on a few major parameters such as effective gene network connectivity, “effective” genome size, proteome turnover and DNA repair rate. The lifespan can be increased by tuning, or hacking any of these parameters.

This hypothesis is supported by the biological evidence, inferred either from evolutionary observations or from various experiments performed by the leading scientists that have significantly extended life expectancy.

For instance, it’s examined how by protecting mitochondrial genes by their transfer to the nuclear genome, or by establishment of the nuclear envelope, the effective interactions between the genes and the cellular environment was substantially reduced.

These events are considered the major factors that led to the formation of multicellular life which in its turn resulted in a dramatic increase in organisms complexity and life expectancy.

Experimental reduction of the network connectivity by silencing of kinase cascades involved in regulation of transcription factors leads to a dramatic effect on the lifespan in C. elegans worms (up to a 10x lifespan extension by a single mutation).

The relation between stresses, stress resistance and aging is analysed and demonstrate, that damage to gene regulation from stresses encountered even at a very young age can persist for a very long time and influence lifespan.

That is why we believe that further research into the relation between gene network stability and aging will make it possible to create entirely new therapies with potentially strong and lasting effect against age-related diseases and aging itself.

About Gero
Gero is a drug discovery company designing first in class small molecule therapeutics using proprietary, industry leading molecular modeling and systems biology technologies. 

The company provides answers to the challenges of human anti-aging therapies development that consists of two components: therapeutic targets identification and drug candidates development.

Gero is a team of experts from diverse fields of studies - theoretical physics, drug discovery and development, and IT business. The scientific effort is led by Peter Fedichev, Ph.D, CSO, a former condensed matter physicist, , 

Friday, August 21, 2015

Cycling without Age Comes to America


OSHKOSH, Wis., Aug. 21, 2015 --  Cycling Without Age founder and TEDxCopenhagen co-organizer Ole Kassow will assist Lutheran Homes of Oshkosh (LHO) in launching the first Cycling Without Age movement in America on Monday, Aug. 24.

 
This popular European movement was created to enhance the quality of life for elders in senior living communities by providing free bike rides on rickshaws around the community.

Gov. Scott Walker signed a certificate of commendation to honor LHO's inaugural Cycling Without Age event, and wished them continued good health and success in the future.

Sen. Richard Gudex, Rep. Gordon Hintz and representatives from Gov. Walker and Sen. Ron Johnson's offices will also attend the formal ceremony to show support for the event. 

Gerard Bodalski, LHO's vice president of healthcare services, said the organization wishes to bring multiple generations together to enhance its elders' happiness and connectivity with the Oshkosh community. 

"Lutheran Homes of Oshkosh is committed to creating extraordinary experiences for our elders, their families and our employees," Bodalski said. 

"This innovative, intergenerational opportunity allows our elders to take advantage of the beautiful outdoors, while celebrating their strengths."

The event is only the beginning of a long-term initiative for LHO, whose mission is to provide quality care and life-enriching opportunities for its elders.

Kassow and Dorthe Pedersen, civil society consultant for Copenhagen Municipality, will help train volunteers on how to operate the rickshaws, ensuring a safe ride for elders. 

There will be a formal ceremony starting at 10 a.m. followed by volunteer rickshaw rides for the elders of LHO at 11 a.m.

Visit LHO's Cycling Without Age Facebook and Twitter to learn more about this initiative.

About Lutheran Homes of Oshkosh

Lutheran Homes of Oshkosh (LHO), founded in 1966, is an elder care organization that has been providing health and residential services to more than 800 elders and others in need. LHO strives to create extraordinary experiences for elders and their families.