These are actual photos taken by the lifeblogging app of study participants. They were later shown these photos while in the fMRI and asked to recall the memories associated with the pictures.
A first view of real-life memories ‘on the scale of our lives’
Newswise,
August 18, 2015 — COLUMBUS, Ohio – For the first time, scientists have seen
evidence of where the brain records the time and place of real-life memories.
Results
showed that the similarity of the brain activation patterns when memories were
recalled was an indicator of the breadth of space and time between the actual
events.
Participants
in the Ohio State University study wore a smartphone around their neck with an
app that took random photos for a month. Later, when the participants relived
memories related to those photos in an fMRI scanner, researchers found that a
part of the brain’s hippocampus stores information about where and when their
specific memories occurred.
In
fact, the study, published this week in the Proceedings of the National
Academy of Sciences, showed that the further apart the memories occurred in
space and time, the farther apart the memories’ representations appeared in the
hippocampus.
“What
we’re picking up here is not the whole memory, but the basic gist – the where
and when of the experience,” said Per Sederberg, senior author of the study and
assistant professor of psychology at Ohio State.
“This
could be viewed as the memory hub, where we have these general, large-scale
representations of our experiences.”
Similar
work has been done in rats – in fact the discovery of rat neurons that code for
space won the Nobel Prize in Medicine last year. But in rats, the space they
live in can be measured in feet.
There
have also been studies in humans that ask them to recall lists of words or
other information that they had just seen – but that recorded memories of just
a few minutes that were created under experimental conditions.
This
study greatly expands on both of those dimensions, by looking at real-life
memories in humans.
“We
found that the hippocampus represents time and space for at least a month of
memories spanning up to 30 kilometers (19 miles) in space,” Sederberg said.
“It is the first time we’ve been able to study memories on the scale of our lives.”
“It is the first time we’ve been able to study memories on the scale of our lives.”
Sederberg
led the study with Dylan Nielson, a Ph.D. graduate of Ohio State. Other
co-authors were Troy Smith and Vishnu Sreekumar of Ohio State and Simon Dennis,
a former Ohio State professor now at the University of Newcastle in Australia.
The
study involved nine women aged 19 to 26 who wore an Android-based smartphone on
a strap around their neck for one month. The phone was equipped with a custom
lifeblogging app designed by Dennis. The app would take photos at random times
of the day, recording the time, location, whether the person was moving and
other information.
Over
the course of the month, the phone took an average of about 5,400 photos for
each participant.
After
the month was over, the participants were placed in an fMRI scanner that
measured activity in their brain while they were shown 120 of their own photos.
Participants were asked to try to remember the event depicted in each picture and relive the experience in their mind while viewing the photo for eight seconds.
Participants were asked to try to remember the event depicted in each picture and relive the experience in their mind while viewing the photo for eight seconds.
The
researchers compared fMRI data on pairs of images for each participant. The
photo pairs chosen were taken at least 100 meters and 16 hours apart.
Remembering an experience “lights up” many parts of the brain, but different memories create different patterns of activity.
The more different two memories are, the more different the pattern of activity will be. Results showed that patterns of activity in the left anterior hippocampus were more different for memories of events that happened further apart in time and space.
“If
the participants didn’t recall the images, we didn’t see this relationship,”
Sederberg said.
“We
also don’t get this effect if we only asked about the time and not the place of
the memory. We found that time and space are very much intertwined in our
representations of memories.”
Sederberg
said the representations they found in the left anterior of the hippocampus
aren’t the totality of the memories, but just the broad picture of where and
when it occurred. Other research suggests that the posterior portion of the
hippocampus may “fine-tune” the time and place.
“What
we found may be just the targeting mechanism that gives us the general gist of
the memory. And then there is a process that moves out through the rest of the
hippocampus and spreads out through the cortex as we relive the entirety of the
memory,” he said.
Sederberg
noted that the hippocampus is one of the first areas of the brain to degrade in
Alzheimer’s disease.
“People
with Alzheimer’s may forget experiences and people because they are not able to
effectively target their old memories. They can’t retrieve memories because
they can’t get the right general cue to get to that memory,” he said.
That’s one of the issues he would like to explore in future studies. Sederberg said he hopes to repeat this study with people of different ages and with people who are showing early signs of dementia to see how their brains are representing their memories.
He
also plans to collect months or even a year’s worth of data to see how we
target memories over even longer periods of time and greater distances.
“We’ve
got a decade or more of work ahead of us. This is just the first step,”
Sederberg said.
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